First evidence of spatial clustering of lymphatic filariasis in an Aedes polynesiensis endemic area.
Identifieur interne : 004E78 ( Main/Exploration ); précédent : 004E77; suivant : 004E79First evidence of spatial clustering of lymphatic filariasis in an Aedes polynesiensis endemic area.
Auteurs : Hayley Joseph [Australie] ; James Moloney ; Fuatai Maiava ; Shannon Mcclintock ; Patrick Lammie ; Wayne MelroseSource :
- Acta tropica [ 1873-6254 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Aedes (parasitologie), Aedes (physiologie), Analyse de regroupements, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (transmission), Filariose lymphatique (épidémiologie), Humains, Jeune adulte, Lutte contre les moustiques, Microfilaria (immunologie), Microfilaria (isolement et purification), Mâle, Population rurale, Prévalence, Samoa (épidémiologie), Sensibilité et spécificité, Systèmes d'information géographique, Test ELISA, Vecteurs insectes (parasitologie), Wuchereria bancrofti (immunologie).
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Filariose lymphatique, Microfilaria, Wuchereria bancrofti.
- isolement et purification : Microfilaria.
- parasitologie : Aedes, Vecteurs insectes.
- physiologie : Aedes.
- sang : Anticorps antihelminthe, Antigènes d'helminthe.
- épidémiologie : Filariose lymphatique, Samoa.
- Adolescent, Adulte, Analyse de regroupements, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Lutte contre les moustiques, Mâle, Population rurale, Prévalence, Sensibilité et spécificité, Systèmes d'information géographique, Test ELISA.
English descriptors
- KwdEn :
- Adolescent, Adult, Aedes (parasitology), Aedes (physiology), Animals, Antibodies, Helminth (blood), Antigens, Helminth (blood), Child, Child, Preschool, Cluster Analysis, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (transmission), Enzyme-Linked Immunosorbent Assay, Female, Geographic Information Systems, Humans, Insect Vectors (parasitology), Male, Microfilariae (immunology), Microfilariae (isolation & purification), Mosquito Control, Prevalence, Rural Population, Samoa (epidemiology), Sensitivity and Specificity, Wuchereria bancrofti (immunology), Young Adult.
- MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial, Samoa.
- immunology : Elephantiasis, Filarial, Microfilariae, Wuchereria bancrofti.
- isolation & purification : Microfilariae.
- parasitology : Aedes, Insect Vectors.
- physiology : Aedes.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Child, Preschool, Cluster Analysis, Enzyme-Linked Immunosorbent Assay, Female, Geographic Information Systems, Humans, Male, Mosquito Control, Prevalence, Rural Population, Sensitivity and Specificity, Young Adult.
Abstract
Successful elimination of lymphatic filariasis (LF) requires accurate identification of residual foci of transmission and stringent surveillance strategies to combat potential resurgence. This is challenging in areas where the day-biting Aedes polynesiensis is endemic, such as Samoa, since in previous studies no geographical clustering of infection has been demonstrated. Another challenge for this low prevalence phase is the choice of diagnostic assay as testing for circulating filarial antigen (CFA) or microfilariae (Mf) alone may not have adequate sensitivity. This could be solved by using the commercially available filariasis Cellabs enzyme linked immunosorbent assay (CELISA) to measure antibody. In the current study five Samoan villages were chosen based on previous epidemiological assessments to represent a range of infection prevalences. CFA, Mf, and antibody levels in children ≤ 10 years had been recorded and results linked to household of residence and/or primary school of attendance. To ascertain the location of exposure, two scenarios based on potential foci of transmission around communities and schools were explored. Both scenarios revealed significant spatial clusters of households with infected individuals and a relationship to antibody positive children when they were included in the spatial analysis. Fasitoo-Tai had the highest LF prevalence and largest geographical spatial clusters for both scenarios. In Falefa, spatial clusters were detected only for the primary school scenario. In Tafua, which spanned an area of 19.5 km(2), no spatial clusters were detected. Lastly, in Siufaga, the village with the lowest LF prevalence, significant clustering of infected individuals was observed and, for the primary school scenario, this was geographically related to exposure. These promising findings are the first published evidence of spatial clustering of LF in a day-biting Ae. polynesiensis endemic area.
DOI: 10.1016/j.actatropica.2010.12.004
PubMed: 21172296
Affiliations:
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Moloney</name></author><author><name sortKey="Maiava, Fuatai" sort="Maiava, Fuatai" uniqKey="Maiava F" first="Fuatai" last="Maiava">Fuatai Maiava</name></author><author><name sortKey="Mcclintock, Shannon" sort="Mcclintock, Shannon" uniqKey="Mcclintock S" first="Shannon" last="Mcclintock">Shannon Mcclintock</name></author><author><name sortKey="Lammie, Patrick" sort="Lammie, Patrick" uniqKey="Lammie P" first="Patrick" last="Lammie">Patrick Lammie</name></author><author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21172296</idno><idno type="pmid">21172296</idno><idno type="doi">10.1016/j.actatropica.2010.12.004</idno><idno type="wicri:Area/PubMed/Corpus">002807</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002807</idno><idno 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Systems</term><term>Humans</term><term>Insect Vectors (parasitology)</term><term>Male</term><term>Microfilariae (immunology)</term><term>Microfilariae (isolation & purification)</term><term>Mosquito Control</term><term>Prevalence</term><term>Rural Population</term><term>Samoa (epidemiology)</term><term>Sensitivity and Specificity</term><term>Wuchereria bancrofti (immunology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Aedes (parasitologie)</term><term>Aedes (physiologie)</term><term>Analyse de regroupements</term><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (transmission)</term><term>Filariose lymphatique 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regroupements</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lutte contre les moustiques</term><term>Mâle</term><term>Population rurale</term><term>Prévalence</term><term>Sensibilité et spécificité</term><term>Systèmes d'information géographique</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Successful elimination of lymphatic filariasis (LF) requires accurate identification of residual foci of transmission and stringent surveillance strategies to combat potential resurgence. This is challenging in areas where the day-biting Aedes polynesiensis is endemic, such as Samoa, since in previous studies no geographical clustering of infection has been demonstrated. Another challenge for this low prevalence phase is the choice of diagnostic assay as testing for circulating filarial antigen (CFA) or microfilariae (Mf) alone may not have adequate sensitivity. This could be solved by using the commercially available filariasis Cellabs enzyme linked immunosorbent assay (CELISA) to measure antibody. In the current study five Samoan villages were chosen based on previous epidemiological assessments to represent a range of infection prevalences. CFA, Mf, and antibody levels in children ≤ 10 years had been recorded and results linked to household of residence and/or primary school of attendance. To ascertain the location of exposure, two scenarios based on potential foci of transmission around communities and schools were explored. Both scenarios revealed significant spatial clusters of households with infected individuals and a relationship to antibody positive children when they were included in the spatial analysis. Fasitoo-Tai had the highest LF prevalence and largest geographical spatial clusters for both scenarios. In Falefa, spatial clusters were detected only for the primary school scenario. In Tafua, which spanned an area of 19.5 km(2), no spatial clusters were detected. Lastly, in Siufaga, the village with the lowest LF prevalence, significant clustering of infected individuals was observed and, for the primary school scenario, this was geographically related to exposure. These promising findings are the first published evidence of spatial clustering of LF in a day-biting Ae. polynesiensis endemic area.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Lammie, Patrick" sort="Lammie, Patrick" uniqKey="Lammie P" first="Patrick" last="Lammie">Patrick Lammie</name><name sortKey="Maiava, Fuatai" sort="Maiava, Fuatai" uniqKey="Maiava F" first="Fuatai" last="Maiava">Fuatai Maiava</name><name sortKey="Mcclintock, Shannon" sort="Mcclintock, Shannon" uniqKey="Mcclintock S" first="Shannon" last="Mcclintock">Shannon Mcclintock</name><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name><name sortKey="Moloney, James" sort="Moloney, James" uniqKey="Moloney J" first="James" last="Moloney">James Moloney</name></noCountry><country name="Australie"><noRegion><name sortKey="Joseph, Hayley" sort="Joseph, Hayley" uniqKey="Joseph H" first="Hayley" last="Joseph">Hayley Joseph</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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